This book presents diseases to the students with their classical features and presentation; with this the latest updated management from the recent guidelines. This book comprises of nine sections; the first section is about cardiology which is the favorite topic of examiners, which, includes classical findings and latest updated treatment of pericardial, myocardial and eo diseases. Second section is about respiratory disease, another frequently asked section, and has become very important due to recent advances in management of asthma and interstitial lung diseases. Third section is about renal system where the book mainly focuses on approach to renal diseases. Fourth section is about critical care which comprises of four different chapters, namely respiratory critical care, neurocritical care, cardiocritical care and oncological emergencies. Fifth section is about neurology where central nervous system and immune mediated diseases are discussed in detail. Sixth section is about endocrinology, where latest updates regarding management of diabetes and obesity have been covered. Seventh section describes one of the favorite topics of examiners I.E. Rheumatology, where we have covered connective tissue disorders and also added Chapter on Igg4 related diseases. Eighth section is about gastroenterology and hepatology here we have latest management guidelines available for the diseases. Ninth section covers the most important part for the exams I.E. Infectious disease, since India is a tropical country and has its own guidelines for infectious diseases like NACO and RNTCP.